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Matthew M Ames Selected Research

NSC 366140 (pyrazoloacridine)

10/2005Phase I/II trial of pyrazoloacridine and carboplatin in patients with recurrent glioma: a North Central Cancer Treatment Group trial.
2/2004The metabolism of pyrazoloacridine (NSC 366140) by cytochromes p450 and flavin monooxygenase in human liver microsomes.
8/2002A phase I and pharmacologic study of pyrazoloacridine (NSC 366140) and carboplatin in patients with advanced cancer.

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Matthew M Ames Research Topics

Disease

59Neoplasms (Cancer)
01/2022 - 02/2002
17Breast Neoplasms (Breast Cancer)
01/2020 - 12/2005
7Neutropenia
09/2013 - 02/2002
6Thrombocytopenia (Thrombopenia)
09/2013 - 09/2005
5Glioma (Gliomas)
11/2015 - 10/2005
5Leukemia
04/2013 - 09/2005
4Nausea
03/2013 - 08/2005
4Carcinoma (Carcinomatosis)
01/2012 - 04/2005
3Pancreatic Neoplasms (Pancreatic Cancer)
01/2019 - 03/2008
3Adenocarcinoma
01/2019 - 03/2008
3Neuroblastoma
04/2014 - 07/2006
3Anorexia
03/2013 - 04/2010
3Vomiting
02/2013 - 08/2005
3Carcinoid Tumor (Carcinoid)
09/2010 - 04/2005
2Hemorrhagic Cystitis
06/2016 - 06/2015
2Exanthema (Rash)
07/2014 - 02/2013
2Fatigue
04/2014 - 02/2013
2Anemia
09/2013 - 02/2013
2Colorectal Neoplasms (Colorectal Cancer)
01/2013 - 05/2007
2Glioblastoma (Glioblastoma Multiforme)
11/2012 - 04/2009
2Abdominal Pain (Pain, Abdominal)
04/2010 - 07/2006
2Diarrhea
04/2010 - 08/2005
2Neoplasm Metastasis (Metastasis)
04/2008 - 03/2007
2Typhlitis
04/2008 - 09/2005
2Dehydration (Water Stress)
07/2006 - 08/2005
1Aggressive Fibromatosis (Desmoid)
02/2021
1Hodgkin Disease (Hodgkin's Disease)
01/2018
1Hemorrhage
06/2015
1Inflammation (Inflammations)
06/2015
1Hyperplasia
12/2014
1Endometrial Neoplasms (Endometrial Cancer)
12/2014

Drug/Important Bio-Agent (IBA)

16TamoxifenFDA LinkGeneric
02/2021 - 12/2005
11Cytochrome P-450 CYP2D6 (CYP2D6)IBA
10/2017 - 12/2005
104-hydroxy-N-desmethyltamoxifenIBA
01/2022 - 12/2005
9DNA (Deoxyribonucleic Acid)IBA
10/2017 - 07/2002
9VorinostatFDA Link
04/2014 - 04/2009
8Irinotecan (Camptosar)FDA LinkGeneric
09/2017 - 10/2003
8EnzymesIBA
11/2015 - 04/2005
7GemcitabineFDA Link
01/2019 - 06/2004
4Estrogen ReceptorsIBA
01/2020 - 01/2013
4Fluorouracil (Carac)FDA LinkGeneric
09/2017 - 03/2002
4Bortezomib (Velcade)FDA Link
04/2014 - 03/2013
4alvocidib (flavopiridol)IBA
04/2013 - 08/2005
4Carboplatin (JM8)FDA LinkGeneric
10/2005 - 08/2002
3Pharmaceutical PreparationsIBA
01/2020 - 06/2015
3Oxaliplatin (Eloxatin)FDA LinkGeneric
09/2017 - 10/2003
3Anticonvulsants (Antiepileptic Drugs)IBA
11/2015 - 10/2005
3Antineoplastic Agents (Antineoplastics)IBA
06/2015 - 07/2002
3ParaffinIBA
12/2014 - 12/2005
3FenretinideIBA
04/2014 - 07/2006
3tanespimycin (17AAG)IBA
10/2013 - 01/2008
3Temozolomide (Temodar)FDA LinkGeneric
09/2013 - 04/2010
3Pemetrexed (MTA)FDA Link
02/2013 - 03/2007
3ErbB Receptors (EGF Receptor)IBA
04/2008 - 10/2005
3NSC 366140 (pyrazoloacridine)IBA
10/2005 - 08/2002
2Hormones (Hormone)IBA
02/2021 - 10/2009
2batracylinIBA
06/2016 - 06/2015
2Alkaline PhosphataseIBA
07/2014 - 07/2006
2Histone Deacetylase InhibitorsIBA
09/2013 - 04/2009
2Raloxifene Hydrochloride (Evista)FDA Link
07/2013 - 11/2011
2Selective Estrogen Receptor Modulators (SERM)IBA
07/2013 - 11/2011
2Proteins (Proteins, Gene)FDA Link
11/2011 - 05/2006
2aminoflavoneIBA
08/2010 - 07/2002
2Cytochrome P-450 CYP1A1 (CYP1A1)IBA
08/2010 - 07/2002
2Paclitaxel (Taxol)FDA LinkGeneric
08/2010 - 04/2008
2Folic Acid AntagonistsIBA
09/2007 - 03/2007
2Leucovorin (Folinic Acid)FDA Link
05/2007 - 10/2003
2Cyclin-Dependent Kinases (cdk Proteins)IBA
12/2005 - 08/2005
2Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
12/2005 - 07/2002
2Topotecan (Hycamtin)FDA LinkGeneric
09/2005 - 02/2002
2Cisplatin (Platino)FDA LinkGeneric
08/2005 - 02/2002
1Fulvestrant (Faslodex)FDA Link
01/2020
1exemestane (Aromasin)FDA Link
01/2020
1Aromatase InhibitorsIBA
01/2020
1EverolimusFDA Link
01/2020
1Letrozole (Femara)FDA LinkGeneric
01/2020
1Erlotinib Hydrochloride (CP 358,774)FDA Link
01/2019
1Panitumumab (Vectibix)FDA Link
01/2019
1Bleomycin (Blenoxane)FDA LinkGeneric
01/2018
1Doxorubicin (Adriamycin)FDA LinkGeneric
01/2018
15- (3- methyl- 1- triazeno)imidazole- 4- carboxamide (MTIC)IBA
01/2018
1Dacarbazine (DIC)FDA LinkGeneric
01/2018
1Vinblastine (Vinblastine Sulfate)FDA Link
01/2018
15- (3- hydroxymethyl- 3- methyl- 1- triazeno)imidazole- 4- carboxamide (HMIC)IBA
01/2018
1Cell-Free Nucleic AcidsIBA
10/2017
1Glucuronosyltransferase (UDP Glucuronosyltransferase)IBA
09/2017
1Capecitabine (Xeloda)FDA Link
09/2017
1IfosfamideFDA LinkGeneric
06/2015
1DNA TopoisomerasesIBA
06/2015
1Mesna (Coenzyme M)FDA LinkGeneric
06/2015
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
06/2015
1Formaldehyde (Formol)FDA Link
12/2014
1A-Form DNA (A-DNA)IBA
12/2014
1Estrogens (Estrogen)FDA Link
12/2014
1Biological ProductsIBA
07/2014
1MK 2206IBA
07/2014

Therapy/Procedure

15Therapeutics
02/2021 - 09/2005
3Radiotherapy
11/2012 - 06/2003
2Oral Administration
06/2015 - 01/2008
2Chemoprevention
11/2011 - 03/2008